کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2491538 1115088 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Are xenogeneic anti-tissue transglutaminase antibodies the holy grail for celiac patients?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Are xenogeneic anti-tissue transglutaminase antibodies the holy grail for celiac patients?
چکیده انگلیسی

SummaryCeliac disease is an immune mediated disorder, the only one with a well-established origin, resulting from a permanent gluten intolerance. Although a gluten-free diet is currently the “safe” and appropriate therapy for celiac disease, this is not always an easy and simple option as “harmful” gluten may contaminate food during the processing and preparation phases. There are also further social pressures, which might be more pressing for young celiac patients, in following a strict gluten-free diet. Therefore, a new therapeutic approaches are sought which would permit celiacs to “peacefully” coexist with gluten. Presently, the most promising looks search for genetically modified wheat lacking toxic gluten peptides and the use of oral endopeptidases in attempt to curb gluten toxicity.Recently discovered role of anti-tissue transglutaminase antibodies in celiac pathogenesis has brought a prospect for a new hypothetical therapeutic approach, an oral immunization of celiacs with xenogeneic anti-tissue transglutaminase antibodies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 69, Issue 6, 2007, Pages 1257–1260
نویسندگان
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