کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2491730 1115092 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sporadic amyotrophic lateral sclerosis as an infectious disease: A possible role of cyanobacteria?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Sporadic amyotrophic lateral sclerosis as an infectious disease: A possible role of cyanobacteria?
چکیده انگلیسی

SummaryThe available epidemiological data for amyotrophic lateral sclerosis (ALS) support an infectious etiology and lead us to propose a new hypotheses. We examined older epidemiological data concerning categories of the population with increased incidence (aged people, people living in rural areas, farmers, breeders), more recent epidemiological reports regarding Italian soccer players, AIDS patients, people living in highly polluted areas, and reports of cases of conjugal and pregnancy-associated ALS. The toxic and infectious hypotheses lead us to suggest a role for cyanobacteria in the production of endogenous β-N-methylamino-l-alanine. Infection from a cyanobacterium, or another ubiquitous bacterium having similar characteristics, may be the missing clue to the etiology of ALS. We speculate that ubiquitous bacteria secreting toxic amino acids and “colonizing” tissues and organs in the human body might be the common element linking motor neuron diseases in Guam to sporadic ALS in the rest of the world.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 67, Issue 6, 2006, Pages 1363–1371
نویسندگان
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