کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2492089 1115099 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Does a mutated X-linked dominant transcriptional repressor gene explain mirror writing ability and synaesthesia?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Does a mutated X-linked dominant transcriptional repressor gene explain mirror writing ability and synaesthesia?
چکیده انگلیسی

SummaryX-linked dominant conditions tend to present as two distinct sex-dependent phenotypes. Mirror writing ability and synaesthesia both appear to fall into this category. The existence of two different phenotypes in these two conditions is advanced as a reason associated with regarding their genetic mode of transmission as being X-linked dominant. The alternative autosomal mode cannot account for different male and female phenotypes.It is suggested that the gene for mirror writing ability, a trait linked to non-right-handedness, negates the normal process of left-lateralisation of language. Similarities between mirror writing ability and synaesthesia are documented and it is further suggested that these similarities can be explained if the genes for each condition are regarded as target genes for the same mutated X-linked dominant transcriptional repressor gene, possibly MeCP2.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 69, Issue 2, 2007, Pages 368–371
نویسندگان
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