Carcinogens and endemic squamous cancer of the oesophagus in Transkei, South Africa. Environmental initiation is the dominant factor; tobacco or other carcinogens of low potency or concentration are sufficient for carcinogenesis in the predisposed mucosa

Carcinogenesis for the oesophagus in Transkei is solely or predominantly due to agents which are already known, including tobacco, acting on a predisposed mucosa. The search for further carcinogens is of low importance, and the search for a single potent carcinogen is misguided. What is of importance is the development of methods to reduce the risks associated with predisposing factors and with known carcinogens.