کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2492784 1115118 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Retino-hypothalamic-pineal hypothesis in the pathophysiology of primary headaches
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Retino-hypothalamic-pineal hypothesis in the pathophysiology of primary headaches
چکیده انگلیسی

SummaryPrimary headaches include migraine, tension, cluster headaches, paroxysmal hemicrania and miscellaneous headaches unassociated with structural lesions. A putative role of the retino-hypothalamic-pineal (RHP) axis in the pathophysiology of primary headaches is reviewed in terms of (1) retinal dysfunction, (2) hypothalamic dysfunction and human circadian desynchrony, (3) pineal melatonin dysfunction and (4) rostral limbic dysfunction mediating the human stress response. Unified RHP hypothesis is proposed, suggesting that an acute, periodic or chronic, circadian desynchrony and dysfunction of the whole or part of the RHP axis is implicated in the pathophysiology of primary headaches. Supportive evidence for the RHP hypothesis, including recent PET studies showing changes in dorsal pons, hypothalamus and rostral limbic structures, is presented.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 66, Issue 6, 2006, Pages 1146–1151
نویسندگان
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