کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2495574 | 1116069 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development and validation of spectrophotometric method of cefpodoxime proxetil using hydrotropic solubilizing agents
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
پزشکی مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Purpose: To develop and validate specific and accurate UV spectrophotometric method of cefpodoxime proxetil by using different hydrotropic solubilizing agents. Materials and Methods: The present study deals with spectrophotometric analysis of cefpodoxime proxetil by utilizing 4 different hydrotropic agents such as ammonium acetate (6 M), sodium citrate (1.25 M), sodium gycinate (1 M), sodium chloride (1 M), and urea (1 M). Results: From different hydrotropic agents, urea showed best aqueous solubility of cefpodoxime proxetil. The linearity was observed in the concentration range of 10-120 μg/ml. The method was validated and found to be precise. Accuracy (percent recovery) for cefpodoxime proxetil was found to be 99.82 ± 0.106. Conclusion: Urea as hydrotropic agent showed best aqueous solubility of cefpodoxime proxetil, which can be used as solubilizing agent. The proposed method is new, simple, safe, eco-friendly, economic, accurate, and cost-effective and can be successfully employed in routine analysis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmaceutical Methods - Volume 3, Issue 2, JulyâDecember 2012, Pages 117-120
Journal: Pharmaceutical Methods - Volume 3, Issue 2, JulyâDecember 2012, Pages 117-120
نویسندگان
Geet Asnani, Kiran Jadhav, Dinesh Dhamecha, Ashwini Sankh, Mrityunjaya Patil,