کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2496779 1116164 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of yokukansan on behavioral and psychological symptoms of vascular dementia: An open-label trial
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Effects of yokukansan on behavioral and psychological symptoms of vascular dementia: An open-label trial
چکیده انگلیسی

Previous clinical trials suggest that the traditional Japanese medicine yokukansan has beneficial effects on the behavioral and psychological symptoms of dementia (BPSD). The present study was conducted to elucidate the efficacy of yokukansan on BPSD in patients with vascular dementia. Thirteen Japanese patients (9 men and 4 women) who were diagnosed as having vascular dementia (VaD) according to the diagnostic criteria of NINDS-AIREN were subjected to the open-label clinical trial in which yokukansan (7.5 g/day) has been given for 4 weeks. Their mean age was 71.2 ± 6.5 years. The BPSD was evaluated using the Neuropsychiatric Inventory (NPI), cognitive function was evaluated by the Mini-Mental State Examination (MMSE), the activities of daily living was evaluated by Barthel index (BI) and Disability Assessment for Dementia (DAD), and the extrapyramidal signs were evaluated by United Parkinson's Disease Rating Scale (UPDRS). The mean NPI was 33.0 ± 17.3 and 23.6 ± 13.9 for the baseline and after treatment, respectively. It was significantly improved after treatment (p < 0.05). In the NPI-subcategories, there was a significant improvement in agitation and disinhibition after the treatment. There was no significant change in MMSE, BI, DAD or UPDRS before and after the treatment. There was no adverse effect during the treatment period. The present results suggest that yokukansan is beneficial for the treatment of BPSD in VaD patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 19, Issue 6, 15 April 2012, Pages 524–528
نویسندگان
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