کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2496878 1116171 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products
چکیده انگلیسی

Glycyrrhiza glabra and its phytoconstituents have been known to possess widespread pharmacological properties as an anti-inflammatory, anti-viral, antitumour and hepatoprotective drug. In this study, we examined the inhibitory potential of extract of G. glabra (GutGard™) root and its phytoconstituents (glabridin, glycyrrhizin, and isoliquiritigenin) on both cyclooxygenase (COX) and lipoxygenase (LOX) products in order to understand the mechanism of its anti-inflammatory action. Inhibitory effect of GutGard™ and its phytoconstituents on lipopolysaccharide (LPS) induced prostaglandin E2 (PGE2), calcimycin (A23187) induced thromboxane (TXB2), and leukotriene (LTB4) release was studied using murine macrophages (J774A.1) and human neutrophil (HL-60) cells. Results revealed that, G. glabra and glabridin significantly inhibited PGE2, TXB2 (COX) and LTB4 (LOX), while, isoliquiritigenin exerted inhibitory effect only against COX products but failed to suppress LOX product. However, glycyrrhizin at the tested concentrations failed to exhibit inhibitory effect on both COX and LOX products. Here, we report for the first time that G. glabra (almost devoid of glycyrrhizin) exhibits anti-inflammatory property likely through the inhibition of PGE2, TXB2 and LTB4 in mammalian cell assay system, which could be influenced in part by glabridin and isoliquiritigenin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 18, Issue 4, 15 February 2011, Pages 278–284
نویسندگان
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