کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2497413 1116201 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety
چکیده انگلیسی

Crocus sativus L. is a plant cultivated in various parts of the world. Crocins are among the active components of Crocus sativus L. The present study was designed to investigate in the rat whether or not crocins possess anxiolytic properties. For this aim, the light/dark test was selected. Either crocins, at a dose which did not influence animals’ motor activity (50 mg/kg), or diazepam (1.5 mg/kg), significantly increased the latency to enter the dark compartment and prolonged the time spent in the lit chamber in the rats. Conversely, lower doses of crocins (15–30 mg/kg) did not substantially modify animals’ behaviour. The present results indicate that treatment with these active constituents of Crocus sativus L. induce anxiolytic-like effects in the rat.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 15, Issue 12, December 2008, Pages 1135–1139
نویسندگان
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