کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2497469 1116205 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of Camphor–Crataegus berry extract combination on blood pressure and mental functions in chronic hypotension – A randomized placebo controlled double blind design
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
The effect of Camphor–Crataegus berry extract combination on blood pressure and mental functions in chronic hypotension – A randomized placebo controlled double blind design
چکیده انگلیسی

A number of studies have provided evidence for reduced cognitive performance due to chronically low blood pressure. The present studies explored whether these deficits can be reduced by pharmacological blood pressure elevation. Effects of the Camphor–Crataegus berry extract combination (Korodin®) were investigated in two studies with 40 and 48 hypotensive women based on a randomized, placebo controlled double blind design. The participants were presented with different tasks assessing performance in attention and cognition. Blood pressure was measured repeatedly during the experiment.The administration of the drug led to positive and differential effects on blood pressure and cognitive performance as compared to placebo. These effects were already visible within the time range of 2–5 min. A positive correlation between blood pressure increase and performance enhancement could be demonstrated for two of the four tasks.The results show that the application of Korodin® results in beneficial effects on resting blood pressure and cognitive performance. The positive association between the increase in blood pressure and cognitive enhancement suggests that blood pressure plays a causal role in the cognitive deficits in hypotension and underlines that they can be reduced through antihypotensive treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 15, Issue 11, November 2008, Pages 914–922
نویسندگان
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