کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2497481 1116205 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antitumor activity of C-21 steroidal glycosides from Cynanchum auriculatum Royle ex Wight
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Antitumor activity of C-21 steroidal glycosides from Cynanchum auriculatum Royle ex Wight
چکیده انگلیسی

The antitumor activities of six C-21 steroidal glycosides isolated from the root tuber of Cynanchum auriculatum Royle ex Wight were performed according to a microculture tetrazolium (MTT) method on human tumor cell lines SMMC-7721, MCF-7 and Hela. Of these compounds, caudatin-2,6-dideoxy-3-O-methy-β-d-cymaropyranoside and caudatin were found to be of the highest effects against human tumor cell line SMMC–7721 with IC50 values of 13.49 and 24.95 μM, respectively. Then the in vivo assay further showed that caudatin-2,6-dideoxy-3-O-methy-β-d-cymaropyranoside and caudatin significantly inhibited the growth of transplantable H22 tumors in mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 15, Issue 11, November 2008, Pages 1016–1020
نویسندگان
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