کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2497626 1116212 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-leukemic activity of Dillenia indica L. fruit extract and quantification of betulinic acid by HPLC
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Anti-leukemic activity of Dillenia indica L. fruit extract and quantification of betulinic acid by HPLC
چکیده انگلیسی

The methanolic extract of Dillenia indica L. fruits showed significant anti-leukemic activity in human leukemic cell lines U937, HL60 and K562. This finding led to fractionation of the methanolic extract, on the basis of polarity, in which the ethyl acetate fraction showed the highest anti-leukemic activity. A major compound, betulinic acid, was isolated from the ethyl acetate fraction by silica gel column chromatography and was identified and characterized. Betulinic acid could explain the anti-leukemic activity of the methanolic extract and the ethyl acetate fraction. Hence the quantitative estimation of betulinic acid was approached in methanolic extract and fractions using HPLC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 17, Issue 6, May 2010, Pages 431–435
نویسندگان
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