کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2498147 1116263 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
STW 5 (Iberogast®) reduces afferent sensitivity in the rat small intestine
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
STW 5 (Iberogast®) reduces afferent sensitivity in the rat small intestine
چکیده انگلیسی

IntroductionA limited number of drugs are available for the treatment of functional dyspepsia and irritable bowel syndrome. The efficacy of STW 5 (Iberogast®) was previously shown in clinical trials. Since visceral hypersensitivity seems to be the prime pathomechanism of functional gastro-intestinal disorders, the aim of this study was to explore whether STW 5 reduces intestinal afferent sensitivity in the upper gastrointestinal tract.MethodsTwo groups of male Wistar rats were pretreated with either the herbal preparation STW 5 or its vehicle (30.8% ethanol). Then, after 2 h, general anesthesia was induced by pentobarbitone (60 mg kg−1 i.p.) and extracellular multi-unit afferent recordings were obtained from mesenteric afferents innervating the proximal jejunum. The intestinal afferent nerve response to increasing doses of 5-HT and bradykinin were quantified as well as afferent discharge following a ramp distension of the adjacent intestinal loop from 0 to 60 cm H2O.ResultsAfferent discharge to 5-HT and bradykinin increased dose-dependently. Following the different doses of 5-HT, the peak in afferent nerve discharge was always reduced after pretreatment with STW 5 compared to controls with a response of 110±5 imp s−1 after STW 5 and 128±3 in vehicle controls at the maximum dose (40 μg kg−1; p<0.05p<0.05; mean±SEM). For bradykinin, afferent responses were reduced following STW 5 at the 20 and 40 μg kg−1 dose but not at 10 μg kg−1 (40 μg kg−1: 176±7 imp s−1 following STW 5 versus 200±6 imp s−1 in controls; p<0.05p<0.05). The ramp distension of the intestinal loop stimulated a rise in intestinal afferent nerve discharge that was always lower in the STW 5 pretreated group compared to vehicle controls with the exception of the discharge rate at the pressure level of 0 and 20 cm H2O (all other pressures up to 60 cm H2O p<0.05p<0.05).ConclusionsSensitivity of intestinal afferents to mechanical and chemical stimuli is reduced following treatment with the herbal preparation STW 5. This mechanism may help to explain why STW 5 relieves dyspeptic and bowel symptoms in patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 13, Supplement 1, 24 November 2006, Pages 100–106
نویسندگان
, , , , , , , ,