کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2526087 1558009 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and evaluation of benzylisoquinoline derivatives for their inhibition on pancreatic lipase and preadipocyte proliferation
ترجمه فارسی عنوان
سنتز و ارزیابی مشتقات بنزلیسوئینولین برای مهار آنها از لیپاز پانکراس و تکثیر پیشدیپوسیت
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب مکمل و جایگزین
چکیده انگلیسی

The present study was designed to synthesize and evaluate a series of benzylisoquinoline derivatives. These compounds were synthesized by Bischler-Napieralski cyclization to yield 1-benzyl-3,4-dihydroisoquinolines, and the products were obtained by reductions. All these compounds were identified by MS, 1H NMR and 13C NMR. The inhibitory activities on pancreatic lipase and preadipocyte proliferation for the synthesized compounds and alkaloids from Nulembo nucifera were assessed in vitro. Most of the compounds showed inhibitory activities on both pancreatic lipase and preadipocyte proliferation. Particularly, compounds 7p–7u and 9d–9f exhibited significant inhibitory activity on pancreatic lipase while compounds 7c, 7d, 7f, 7g, 7i, and 7j potently inhibited the proliferation of 3T3-L1 preadipocytes. Our results provided a basis for future evaluation and development of these compounds as leads for therapeutics for human diseases.

A series of benzylisoquinoline derivatives were designed and synthesized, and all these derivatives were assessed in vitro for their inhibitory activities on pancreatic lipase and preadipocyte proliferation. Most of the compounds showed inhibitory activities on both pancreatic lipase and preadipocyte proliferation.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Journal of Natural Medicines - Volume 14, Issue 5, May 2016, Pages 382–390
نویسندگان
, , , , , , , , ,