A lignin glycoside and a nortriterpenoid from Kadsura coccinea

AimTo study the chemical constituents of the roots and stem bark of Kadsura coccinea.MethodCompounds were isolated by column chromatography on silica gel and Sephadex LH-20, and finally purified by prep-HPLC. Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D-NMR, and HR-ESI-MS.ResultsTwo compounds were determined as (7′S,8′S,8R)-(8β,8′α)-dimethyl-4,4′-dihydroxy-5,3′-dimethoxy-5′-cyclolignan glucoside (1) and micrandiactone H (2), respectively.ConclusionCompunds 1 and 2 are new and neither showed inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-induced RAW264.7 macrophages.