Heteroclitins R-S: new dibenzocylooctadiene lignans from Kadsura heteroclita

AIMTo study the dibenzocylooctadiene lignans from the stems of Kadsura heteroclita.METHODChromatographic separations of silica gel and semi-preparative HPLC were used. All of the structures were elucidated on the basis of spectroscopic analysis, including 2D-NMR and HR-MS techniques.RESULTSFour dibenzocylooctadiene lignans were isolated from K. heteroclita. Their structures were identified as heteroclitin R (1), heteroclitin S (2), gonisin O (3), and schisanlignone A (4).CONCLUSIONHeteroclitin R (1) and heteroclitin S (2) are new natural lignans.