Antifertility activity of Artemisia vulgaris leaves on female Wistar rats

AimTo evaluate the antifertility activity of Artemisia vulgaris leaves on female Wistar rats.MethodThe plant extract was tested for its effect on implant formation at two dose levels, 300 and 600 mg·kg−1, respectively. The effective methanolic plant extract was further studied for estrogenic potency on ovariectomised immature female Wistar rats.ResultsThe data presented in this study demonstrate the antifertility potential of Artemisia vulgaris methanolic leaf extract, which shows a strong and significant decrease in implant formation (100%), and a strong estrogenic effect resulting in a significant increase in uterine weight in immature ovariectomised rats. These observations suggest that the methanolic extract of Artemisia vulgaris leaves has strong anti-implantation activity and estrogenic activity.ConclusionThe methanolic plant extract of A. vulgaris has antifertility activity.