Two new cassane diterpenoids from the seeds of Caesalpinia sappan Linn.

AimTo study the chemical components of the seeds of Caesalpinia sappan.MethodsCompounds were isolated and purified by column chromatography. Their structures were elucidated on the basis of spectroscopic methods. In addition, the cytotoxic activity of these compounds were evaluated using SF-268, MCF-7 and HepG2 cell lines by the MTT assay.ResultsFour cassane diterpenoids were obtained and their structures were identified as phanginin L (1), phanginin M (2), phanginin I (3), phanginin G (4).ConclusionPhanginin L (1) and phanginin M (2) are new cassane diterpenoids. Compound 1 showed moderate cytotoxicity against HepG2 cell line with IC50 of 9.13 μg·mL−1.