Effects of Persimmon Leaf Total Flavonoid on Enzyme of Lipoprotein Metabolism and Antioxidation in Hyperlipidemia Rats

AimTo explore the effects of persimmon leaf total flavonoid (PLF) on regulating the serum level of lipids, enzymes of lipoprotein metabolism and antioxidation in the hyperlipidemia rats.Methods50 healthy SD rats were divided into 5 groups randomly according to the serum TC: hyperlipidemia model group, high dose group of PLF, medium dose group of PLF, low dose group of PLF, and lovastatin treatment positive control group. Serum lipoprotein level, lipoprotein lipase (LPL), hepatic lipase (HL), superoxide dismutase (SOD) and malondialdehyde (MDA) were tested after treated with corresponding drugs once per day for 4 weeks.ResultsCompared with the model group, the levels of the serum TC, TG, LDL-C, and MDA decreased significantly, while HDL-C, LPL, HL and SOD increased significantly (P < 0.05 or P < 0.01).ConclusionThe lipid metabolic disorder in hyperlipidemic rats was improved notably through the treatment with PLF, indicating that the PLF plays an important role in decreasing lipids.