کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2526605 1558051 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brazilein, a Selective 5-HT Receptors Antagonist in Mouse Uterus
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب مکمل و جایگزین
پیش نمایش صفحه اول مقاله
Brazilein, a Selective 5-HT Receptors Antagonist in Mouse Uterus
چکیده انگلیسی

AimTo prove brazilein's effect on 5-HT receptor and to understand the characteristics of the action.MethodsIn this work, the blocking effect of brazilein on 5-HT receptor subtypes was investigated in isolated uterine strips using pharmacological (selective agonists) and molecular biological (real time PCR) approaches.Resultsbrazilein does not affect the contractions of normal mice uterus, but inhibits uterine excitatory elicited by ergometrine maleate (pA2 = 5.71 ± 0.21), a 5-HT2 receptor agonist. The excitatory effects of 5-HT1D, 5-HT2A and 5-HT2C receptor agonists on uterus could be inhibited by brazilein (pA2 = 4.58 ± 0.06, 4.91 ± 0.15, 5.38 ± 0.15, respectively). The mRNA expression of 5-HT1D and 5-HT2C receptors in mice uterus were decreased by brazilein.Conclusionbrazilein blocked 5-HT receptors in mice uterus and might affect the functions mediated by 5-HT receptors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Journal of Natural Medicines - Volume 9, Issue 5, September 2011, Pages 338-344