کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2526617 | 1558052 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dopaminergic Alkaloids from Menispermum dauricum
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
طب مکمل و جایگزین
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
AimTo study the bioactive components of the rhizoma of Menispermum dauricum.MethodsRepeated column chromatography was used for the separation of the compounds and various spectroscopic techniques were applied for structural determination.ResultsEight compounds, meniscoside (1), dauricoside (2), dauriporphine (3), menisporphine (4), bianfugecine (5), 2, 3-dihydromenisporphine (6), syringaresinol (7), and syringaresinol 4, 4′-O-bis-glucoside (8) were obtained and identified. The effects on D1 and D2 receptors labeled with [3H] were evaluated.ConclusionCompound 1 was a new glucosidic benzylisoquinoline. Compounds 1-6 showed significant selective affinity to D1 receptor, and the IC50 of 1 and 2 were 9.2 and 2.0 μmol·L−1, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Journal of Natural Medicines - Volume 9, Issue 4, July 2011, Pages 249-252
Journal: Chinese Journal of Natural Medicines - Volume 9, Issue 4, July 2011, Pages 249-252