Two Antifungal Active Triterpene Glycosides from Sea Cucumber Holothuria (Microthele) axiloga

ABSTRACTAIMTo study the new antifungal active triterpene glycosides of sea cucumber Holothuria (Microthele) axiloga.METHODSTriterpene glycosides from Holothuria (Microthele) axiloga were separated and purified by silica gel chromatography, reversed-phase silica gel chromatography and RP-HPLC. Their structures were elucidated on the basis of chemical evidence, spectral data and chemical reactions.RESULTSTwo triterpene glycosides were identified as axilogoside A (1) and holothurin B (2).CONCLUSIONAxilogoside A (1) is a new triterpene glycoside, and 2 was isolated from Holothuria (Microthele) axiloga for the first time. They showed considerable antifungal activities (4⩽MIC80⩽16 μg·mL−1)