Synthesis and Structural Analysis of Mono-dodecanoic Acid Esters of Ginsenoside M1

AimTo study the structures of esterification products derived from ginsenoside M1 and dodecanoic acid.MethodThe esterified compounds were prepared from the reaction of ginsenoside M1 dodecanoic acid and diimide, and pure prodcuts were obtained by Silica gel column chromatography. Their structures were characterized by IR, UPLC/Q TOF MS and NMR (1D and 2D NMR).ResultsStructures of three compounds were elucidated as the esetrified M1 acylated at 3-OH, 4-OH, 6-OH in the glucose moiety in M1, respectively.ConclusionThree new M1 derivatives acylated at the glucose moiety were synthesized.