Synthesis and Cytotoxicity of Oleanolic Acid/N-aryl-N'-hydroxyguanidine Hybrids

AimTo synthesize oleanolic acid/ N-aryl-N'-hydroxyguanidine hybrids and evaluate their antitumor activity.MethodsSubstituted N-aryl-N'-hydroxyguanidines were conjugated with C3-OH of OA via succinyl, giving eight target compounds, whose cytotoxicities against human cancer cells A549, HT-29, BEL-7402 and SMMC-7721 in vitro were evaluated by MTT assay.ResultsEight novel compounds were synthesized and their structures were identified by IR, MS and1 H NMR. The preliminary experimental results showed that 6b, 6e, 6g and 6h had strong cytotoxicity against SMMC-7721.ConclusionThese compounds are worthy of further studies.