A New Biphenyl from the Fermentation Broth of Plant Endophytic Fungus Pestalotiopsis zonata isolated from Cyrtotachys lakka

AimTo investigate the chemical constituents of the fermentation broth of the plant endophytic fungus Pestalotiopsis zonata isolated from Cyrtotachys lakka in Hainan, China.MethodCompounds 1–4 were separated and purified by silica gel chromatography and Sephadex LH-20. Their structures were elucidated by extensive spectroscopic analysis. Compound 1 was tested for its antibacterial activity against the bacteria Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, methicillin resistant Staphylococcus aureus, Acinetobacter baumannii and vancomycin-resistant Enterococcus faecium.ResultsFour compounds including one new compound named 2′-acetyl-4′, 4-dimethoxybiphenyl-2-carbaldehyde (1) were isolated from this fungus. Their IC50 values are 0.75, 0.75, 0.82, 0.81, 0.84, 0.90 and 0.87 μm·mL−1, respectively.ConclusionCompound 1 was a new biphenyl and it shows weak activity towards those bacteria. Compounds 2–4 were isolated from this fungus for the first time.