Synthesis of Analogs of Desmosdumotin C

AimTo synthesize the analogs of desmosdumotin C with better antitumor activity.MethodsThe efficient three-step reaction procedure was employed to prepare analogs of desmosdumotin C. 2, 4, 6-Trihydroxyacetophenone was firstly reacted and then was treated with TMSCHN2 to get the hydroxyl methylation intermediate. Finally, by aldol condensation, the analogs of desmosdumotin C with different substituents on B-ring were prepared by the aldol condensation.Results and Conclusion6 Analogs of desmosdumotin C were prepared and their structures were identified by MS,1H NMR and 13C NMR. The spectral signature of these compounds was summarized, especially for those compounds with tautomers and fluoro substitutent. It is the first time to report the13C NMR of analogs of desmosdumotin C with their tautomers.