Application of Chemomic Release Kinetics to Evaluation of the Release Characteristics of Yinqiaojiedu Tablets

ABSTRACTAIMTo verify the applicability of a new theory for chemomic release kinetics of traditional Chinese medicines using the release characteristics of Yinqiaojiedu tablets.METHODSThe methodological studies of the preparation of chemomic standard spectrum, linearity, precision and stability tests of the chemomes of Yinqiaojiedu tablets were processed by UV spectrophotometry and Kalman filter methods. The chemomic release profiles of Yinqiaojiedu tablets and powders were determined.RESULTThe methodology studies indicated that there was a good linearity of chemomic concentration of Yinqiaojiedu tablets within the range 0.112 to 1.120 mg total herbs / mL (r = 0.999 7). The values of RSD tested at three chemomic levels were 0.05 %, 0.07 % and 0.31 % respectively. The chemomic solutions were stable for 24 h at concentrations of 0.278, 0.556, and 1.120 mg total herb / mL.CONCLUSIONThe chemomic release profiles demonstrated multi-component release kinetics illustrated using a simple visualization approach. The new theory of chemomic release kinetics may advantageously provide a quantitative description for the release of the active agents from traditional Chinese medicines from a conventional dosage form or drug delivery system.