Cellular Absorption of Emodin Influenced by Anthraquinones in Human Intestinal Caco-2 Cells

ABSTRACTAIMTo determine the influence of the absorption characteristics of emodin by the other free anthraquinones in human intestinal Caco-2 cells.METHODSThe intracellular concentrations of emodin were analyzed by a reverse-phase HPLC with Fluorescence Detector system to reveal the absorption characteristics of emodin.RESULTSThe absorption of emodin was reduced by aloe-emodin and physcion conspicuously.CONCLUSIONResults suggest that the mixture of emodin with other free total rhubarb anthraquinones (TRAs) could be more effectively and safely.