کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2530965 | 1558899 | 2016 | 8 صفحه PDF | دانلود رایگان |
Dopaminergic modulations of glutamate receptors are essential for the prefrontal cortical (PFC) behavioral and cognitive functions. In order to understand the effect of dopamine/glutamate interactions on learning and memory, we investigated the effects of intra medial prefrontal cortex (mPFC) injections of dopaminergic agents on ketamine-induced amnesia by using a one-trial passive avoidance task in mice. Pre-training administration of ketamine (5, 10 and 15 mg/kg, i.p.) dose-dependently decreased the memory acquisition of a one-trial passive avoidance task. Pre-training intra-mPFC administration of SKF 38393, D1 receptor agonist and quinpirol D2 receptor agonist, alone did not affect memory acquisition. However, amnesia induced by pre-training ketamine (15 mg/kg) significantly decreased by pretreatment of SKF 38393 (2 and 4 µg/mouse) and quinpirol (0.3, 1 and 3 µg/mouse). Pre-training administration of SCH 23390, D1 receptor antagonist (0.75 and 1 μg/mouse, intra-mPFC), and sulpiride D2 receptor antagonist (3 μg/mouse, intra-mPFC) impaired memory acquisition. In addition, co-pretreatment of different doses of SCH 23390 and sulpiride with lower dose of ketamine (5 mg/kg), which did not induce amnesia by itself, caused inhibition of memory formation. It may be concluded that dopaminergic system of medial prefrontal cortex is involved in the ketamine-induced impairment of memory acquisition.
Journal: European Journal of Pharmacology - Volume 781, 15 June 2016, Pages 45–52