کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2531235 1558912 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Zebrafish models of cardiovascular diseases and their applications in herbal medicine research
ترجمه فارسی عنوان
مدل های زبرا ماهی از بیماری های قلبی عروقی و کاربرد آنها در تحقیقات دارویی گیاهی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی

The zebrafish (Danio rerio) has recently become a powerful animal model for cardiovascular research and drug discovery due to its ease of maintenance, genetic manipulability and ability for high-throughput screening. Recent advances in imaging techniques and generation of transgenic zebrafish have greatly facilitated in vivo analysis of cellular events of cardiovascular development and pathogenesis. More importantly, recent studies have demonstrated the functional similarity of drug metabolism systems between zebrafish and humans, highlighting the clinical relevance of employing zebrafish in identifying lead compounds in Chinese herbal medicine with potential beneficial cardiovascular effects. This paper seeks to summarise the scope of zebrafish models employed in cardiovascular studies and the application of these research models in Chinese herbal medicine to date.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 768, 5 December 2015, Pages 77–86
نویسندگان
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