کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2531379 1558916 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-inflammatory effects of farrerol on IL-1β-stimulated human osteoarthritis chondrocytes
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Anti-inflammatory effects of farrerol on IL-1β-stimulated human osteoarthritis chondrocytes
چکیده انگلیسی

The present study aimed to investigate the anti-inflammatory effects and the underlying molecular mechanism of farrerol on IL-1β-stimulated human osteoarthritis chondrocytes. Chondrocytes were pretreated with farrerol 1 h before IL-1β stimulation. The effects of farrerol on NO and PGE2 production were tested by Griess reagent and ELISA. The effects of farrerol on COX-2, iNOS, Akt, phosphorylated Akt, and NF-κB activation were measured by western blot analysis. The results showed that farrerol remarkably inhibited IL-1β-induced NO and PGE2 production, as well as COX-2 and iNOS expression. Farrerol also inhibited IL-1β-induced NF-κB activation. Furthermore, farrerol significantly inhibited IL-1β-induced phosphorylation of PI3K and Akt. In conclusion, these results indicated that farrerol inhibited IL-1β-induced inflammatory responses in osteoarthritis chondrocytes by blocking PI3K/Akt/NF-κB signaling pathway.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 764, 5 October 2015, Pages 443–447
نویسندگان
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