کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2531754 | 1558947 | 2014 | 8 صفحه PDF | دانلود رایگان |
It has long been considered that fibrosis and fibroblast-to-myofibroblast differentiation are irreversible processes. However, recent data obtained indicates that tissue fibrosis and fibroblast-to-myofibroblast differentiation can indeed be reversed, which offers the possibility of a new therapeutic approach for fibrotic disorders. Here, we discuss the origin of the myofibroblasts and different aspects of their differentiation, especially the key mediators and TGFβ-induced signaling pathways. We also report here a few factors involved in myofiroblast dedifferentiation and several compounds which can reverse the established dedifferentiated myofibroblast, as examples that provide the reader a glimpse of the current trends of approach for discovering useful anti-fibrotic drugs.
Journal: European Journal of Pharmacology - Volume 734, 5 July 2014, Pages 83–90