کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2531897 1558961 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fructose-1,6-bisphosphate induces phenotypic reversion of activated hepatic stellate cell
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Fructose-1,6-bisphosphate induces phenotypic reversion of activated hepatic stellate cell
چکیده انگلیسی

Hepatic stellate cells (HSC) play a key role in liver fibrogenesis. Activation of PPARγ and inhibition of fibrogenic molecules are potential strategies to block HSC activation and differentiation. Aware that the process of hepatic fibrosis involves inflammatory mediators, various anti-inflammatory substances have been studied in an attempt to revert fibrosis. The purpose of this study was to investigate the in vitro effects of fructose-1,6-bisphosphate (FBP) on HSC phenotype reversion. The results demonstrated that FBP induced quiescent phenotype in GRX cells via PPARγ activation. Significant decrease in type I collagen mRNA expression was observed in the first 24 h of treatment. These events preceded the reduction of TGF-β1 and total collagen secretion. Thus, FBP promoted downregulation of HSC activation by its antifibrotic action. These findings demonstrate that FBP may have potential as a novel therapeutic agent for the treatment of liver fibrosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 720, Issues 1–3, 15 November 2013, Pages 320–325
نویسندگان
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