کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2532279 | 1558985 | 2012 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Involvement of the sigma1 receptor in the antidepressant-like effects of fluvoxamine in the forced swimming test in comparison with the effects elicited by paroxetine Involvement of the sigma1 receptor in the antidepressant-like effects of fluvoxamine in the forced swimming test in comparison with the effects elicited by paroxetine](/preview/png/2532279.png)
We studied the involvement of the sigma1 receptor in the antidepressant-like effects of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine in DBA/2 mice using the forced swimming test. The effects of the selective sigma1 receptor antagonist N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino) ethylamine (BD1047) at 1 mg/kg significantly antagonized the anti-immobility elicited by fluvoxamine (10 mg/kg). However, the anti-immobility effects elicited by another SSRI, paroxetine (5 m/kg), were not altered by BD1047. The selective sigma1 receptor agonist 2S-(2α,6α,11R⁎)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol ((+)SKF-10047) elicited dose-dependent anti-immobility effects in DBA/2 mice. BD1047 significantly blocked the anti-immobility effects induced by (+)SKF-10047 at 10 mg/kg. These results suggested that the sigma1 receptor was associated with fluvoxamine-induced antidepressant-like effects but not with paroxetine-induced antidepressant-like effects.
Journal: European Journal of Pharmacology - Volume 696, Issues 1–3, 5 December 2012, Pages 96–100