کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2532443 1559004 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hsp70 promotes synaptic transmission in brain slices damaged by contact with blood clot
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Hsp70 promotes synaptic transmission in brain slices damaged by contact with blood clot
چکیده انگلیسی

Neurotrophic and neuroprotective properties of Hsp70 were studied in olfactory cortex slices of hypertensive rats under normal conditions and under influence of autologous blood (blood clot). Under normal conditions, synaptic response in slices depended on Hsp70 amount in medium. Incubation of slices with Hsp70 showed a biphasic effect on electrogenesis in tissue. Hsp70 (from 0.1 to 3.0 μg/ml) stimulated glutamatergic and GABA-ergic receptor activity. An inhibitory action on synaptic response is detected at increased amounts of Hsp70 (> 4 μg/ml). Pretreatment with Hsp70 (1 and 10 μg/ml) prevented the irreversible inhibition of bioelectric activity in neurons damaged by autologous blood action and interfered with swelling in slices. Our results indicate that exogenous Hsp70 may play a role in the maintenance of neuronal synaptic functions in normal conditions, and protects electrogenesis of brain tissue in strokes.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 677, Issues 1–3, 29 February 2012, Pages 55–62
نویسندگان
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