Endothelial angiotensin-converting enzyme and neutral endopeptidase in isolated human umbilical vein: An effective bradykinin inactivation pathway

► ACE, NEP and APP as a functional inactivating pathway of BK in human umbilical vein. ► ACE and NEP, alone or combined, functionally inactivate BK in human umbilical vein. ► APP does not functionally inactivate BK in human umbilical vein. ► BK inactivation is localized in the endothelial layer.