Efficacy of aminaftone in a rat model of monocrotaline-induced pulmonary hypertension

► In a validated animal model of pulmonary hypertension we tested chronic treatment with aminaftone, a novel inhibitor of endothelin-1 synthesis. ► Aminaftone increased survival, reduced right ventricular and right atrial hypertrophy. ► Aminaftone reduced plasma concentrations of endothelin-1 and medial wall thickness of pulmonary arteries. ► Aminaftone may represent a novel treatment for pulmonary hypertension, possibly in association with other drugs.