کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2532760 1559021 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells
چکیده انگلیسی

The dried root of Saussurea lappa Clarke (Compositae) has been used as a traditional medicine. Dehydrocostus lactone is one of the main bioactive constituents of this medicinal plant. In the present study, the protective effect of dehydrocostus lactone against antimycin A (an inhibitor of mitochondrial complex III)-induced cytotoxicity was investigated in osteoblastic MC3T3-E1 cells. Pre-treatment with dehydrocostus lactone prior to antimycin A exposure significantly prevented mitochondrial membrane potential dissipation, complex IV inactivation, ATP loss, cytochrome c release, intracellular calcium elevation and potassium loss, and reactive oxygen species production induced by antimycin A. These results suggest that dehydrocostus lactone protects osteoblastic MC3T3-E1 cells from antimycin A-induced cell damage through the improved mitochondrial function.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 664, Issues 1–3, 16 August 2011, Pages 1–7
نویسندگان
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