کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2533672 1559061 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Corticotropin-releasing factor receptors and urocortins, links between the brain and the heart
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Corticotropin-releasing factor receptors and urocortins, links between the brain and the heart
چکیده انگلیسی

Corticotropin-releasing factor (CRF), a 41 amino acid peptide, was discovered as a key signal in mediating neuroendocrine, autonomic, and behavioral responses to stress. It was revealed later that there exist additional CRF-like peptides, termed urocortins. The CRF receptor subtype 1 (CRF1 receptor) is predominant in the brain whereas subtype 2 (CRF2 receptor) is highly expressed in the brain and the heart. Both centrally and peripherally administered CRF and urocortins produce significant hemodynamic effects via activation of CRF receptors in the brain and the heart. CRF and urocortins are important neural and cardioactive hormones, and are potentially useful therapy for heart failure.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 632, Issues 1–3, 25 April 2010, Pages 1–6
نویسندگان
, , , , , ,