کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2533861 1559067 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxymatrine–carbenoxolone sodium inclusion compound induces antinociception and increases the expression of GABAAα1 receptors in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Oxymatrine–carbenoxolone sodium inclusion compound induces antinociception and increases the expression of GABAAα1 receptors in mice
چکیده انگلیسی

Oxymatrine–carbenoxolone sodium inclusion compound (OCSIC) has been reported as a novel painkiller, but its effectiveness and mechanism remain unknown. This study investigated the analgesic effects of OCSIC and the possible alterations in the expression of γ-aminobutyric acid type A α1 (GABAAα1) receptors in the central nervous system caused by the compound. The antinociceptive action of the OCSIC was assessed in thermal and chemical behavioral models of nociception. The hot-plate test, tail immersion test, acetic acid-induced abdominal constriction and formalin-induced pain were used in ICR mice. OCSIC was administered intraperitoneally (i.p.) or intracerebroventricularly (i.c.v.). In all cases, OCSIC produced significant dose-dependent antinociceptive effects. In addition, OCSIC (150 mg/kg) increased the expression of positive staining cells of GABAAα1 receptors. These results reveal that the antinociceptive effects of OCSIC may be involved in the central nervous system and the peripheral nervous system. The involvement of GABAA receptors in the antinociceptive effect of OCSIC is now under investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 626, Issues 2–3, 25 January 2010, Pages 244–249
نویسندگان
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