کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2533878 1559064 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters
چکیده انگلیسی

To investigate whether life-long disturbed serotonin neurotransmission may result in adaptive changes of dopaminergic and noradrenergic systems, effects of drugs on stress-induced hyperthermia were studied in serotonin transporter knockout rats. The noradrenalin transporter blocker atomoxetine was more effective in reducing stress-induced hyperthermia, induced by an injection, in serotonin transporter (SERT) knockout (SERT−/−) rats compared to SERT+/+ rats. The dopamine transporter blocker GBR12909 increased the core body temperature in SERT−/− rats, and had no effect on the SERT+/+ rats. Finally, the noradrenalin transporter together with dopamine transporter blocker bupropion was more effective in decreasing the stress of an injection in SERT−/− rats than in SERT+/+ rats. These data suggest that the sensitivity of dopamine and noradrenalin receptors is changed in serotonin transporter knockout rats. The lack of the serotonin transporter in SERT−/− rats might reflect humans with a life-long disturbed serotonin system, making this rat a good model to study possible changes in dopaminergic and noradrenergic systems in psychiatric disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 629, Issues 1–3, 10 March 2010, Pages 7–11
نویسندگان
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