کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2533976 1559069 2009 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mathematical modeling as a tool for planning anticancer therapy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Mathematical modeling as a tool for planning anticancer therapy
چکیده انگلیسی

We review a large volume of literature concerning mathematical models of cancer therapy, oriented towards optimization of treatment protocols. The review, although partly idiosyncratic, covers such major areas of therapy optimization as phase-specific chemotherapy, antiangiogenic therapy and therapy under drug resistance. We start from early cell cycle progression models, very simple but admitting explicit mathematical solutions, based on methods of control theory. We continue with more complex models involving evolution of drug resistance and pharmacokinetic and pharmacodynamic effects. Then, we consider two more recent areas: angiogenesis of tumors and molecular signaling within and among cells. We discuss biological background and mathematical techniques of this field, which has a large although only partly realized potential for contributing to cancer treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 625, Issues 1–3, 25 December 2009, Pages 108–121
نویسندگان
, , ,