کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2533986 1559069 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cadherins as novel targets for anti-cancer therapy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Cadherins as novel targets for anti-cancer therapy
چکیده انگلیسی

The cell adhesion molecules N-, VE- and OB-cadherin have been implicated as regulators of tumor growth and metastasis. We discuss evidence that N- and VE-cadherin play a key role in promoting blood vessel formation and stability, processes which are essential for tumor growth. Secondly, we describe the potential involvement of N- and OB-cadherin in the metastatic process. Finally, studies concerning the effects of the N-cadherin antagonist designated ADH-1 on tumor growth are presented. Collectively, these observations suggest that antagonists of N-, VE- and OB-cadherin would be useful as anti-cancer agents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 625, Issues 1–3, 25 December 2009, Pages 195–198
نویسندگان
, ,