کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2534735 | 1559098 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of three metabolites of propiverine on voltage-dependent L-type calcium currents in human atrial myocytes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of three metabolites of propiverine on voltage-dependent L-type calcium currents in human atrial myocytes Effects of three metabolites of propiverine on voltage-dependent L-type calcium currents in human atrial myocytes](/preview/png/2534735.png)
چکیده انگلیسی
The non-selective muscarinic receptor antagonist propiverine impairs L-type Ca2+ currents (ICa,L) in human detrusor smooth muscle cells and atrial cardiomyocytes. Here, we have investigated the effects of three metabolites of propiverine on human cardiac ICa,L. Propiverine reduced ICa,L with a − logIC50 [M] value of 4.1, M-5 only showed minor effect on ICa,L at high concentrations, M-6 did not influence ICa,L at all. Like the parent compound M-14 also reduced ICa,L (− logIC50 [M] = 4.6). We conclude, that propiverine and M-14 reduce cardiac ICa,L at higher concentrations than in detrusor cells and therefore preferentially reduce ICa,L in the urinary bladder than in the heart.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 598, Issues 1–3, 19 November 2008, Pages 94–97
Journal: European Journal of Pharmacology - Volume 598, Issues 1–3, 19 November 2008, Pages 94–97
نویسندگان
Melinda Wuest, Torsten Christ, Nicole Hiller, Manfred Braeter, Ursula Ravens,