کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2534751 | 1559097 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A non-selective cationic channel activated by diacylglycerol in mouse intestinal myocytes
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Application of 1-oleoyl-2-acetyl-sn-glycerol (OAG), an analogue of diacylglycerol (DAG) formed via M3 muscarinic receptors, induced inward cationic currents via a protein kinase C-independent mechanism and produced membrane depolarization with increased action potential discharges in mouse intestinal myocytes. Outside-out patches from the myocytes responded to OAG with openings of 115-pS channels characterized by a mean open time (Oτ) of 0.15 ms. M3 receptor stimulation is reportedly capable of causing brief openings (Oτ = 0.23 ms) of 120-pS cationic channels in intestinal myocytes, thus the present results strongly support the idea that the M3-mediated 120-pS channel opening is brought about via DAG-dependent mechanisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 599, Issues 1–3, 3 December 2008, Pages 54–57
Journal: European Journal of Pharmacology - Volume 599, Issues 1–3, 3 December 2008, Pages 54–57
نویسندگان
Takashi Sakamoto, Hayato Matsuyama, Masayuki Yamamoto, Yasuyuki Tanahashi, Takio Kitazawa, Tetsuro Taneike, Seiichi Komori, Toshihiro Unno,