کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2534778 1559099 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rebound insomnia induced by abrupt withdrawal of hypnotics in sleep-disturbed rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Rebound insomnia induced by abrupt withdrawal of hypnotics in sleep-disturbed rats
چکیده انگلیسی

The present study was performed to examine whether or not rebound insomnia is caused by an abrupt withdrawal of benzodiazepine hypnotics and tandospirone in rats. Etizolam and triazolam caused a significant shortening of sleep latency, increase in non-REM sleep time, and decrease in wake time in a dose-dependent manner. Etizolam and triazolam caused a significant shortening of sleep latency during drug administration (for 7 days), whereas a significant prolongation of sleep latency was observed by the abrupt withdrawal of these drugs. Tandospirone caused a shortening of sleep latency, whereas no effect was observed on non-REM sleep time and wake time during drug administration (for 7 days). On the other hand, tandospirone showed no significant effect on sleep latency through its abrupt withdrawal, differing from etizolam and triazolam. From these findings, a rebound phenomenon in terms of sleep latency was confirmed with etizolam and triazolam in rats. Furthermore, the 5-HT1A agonist, tandospirone, caused no rebound phenomenon regarding sleep latency in rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 597, Issues 1–3, 12 November 2008, Pages 46–50
نویسندگان
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