کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2534778 | 1559099 | 2008 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Rebound insomnia induced by abrupt withdrawal of hypnotics in sleep-disturbed rats Rebound insomnia induced by abrupt withdrawal of hypnotics in sleep-disturbed rats](/preview/png/2534778.png)
The present study was performed to examine whether or not rebound insomnia is caused by an abrupt withdrawal of benzodiazepine hypnotics and tandospirone in rats. Etizolam and triazolam caused a significant shortening of sleep latency, increase in non-REM sleep time, and decrease in wake time in a dose-dependent manner. Etizolam and triazolam caused a significant shortening of sleep latency during drug administration (for 7 days), whereas a significant prolongation of sleep latency was observed by the abrupt withdrawal of these drugs. Tandospirone caused a shortening of sleep latency, whereas no effect was observed on non-REM sleep time and wake time during drug administration (for 7 days). On the other hand, tandospirone showed no significant effect on sleep latency through its abrupt withdrawal, differing from etizolam and triazolam. From these findings, a rebound phenomenon in terms of sleep latency was confirmed with etizolam and triazolam in rats. Furthermore, the 5-HT1A agonist, tandospirone, caused no rebound phenomenon regarding sleep latency in rats.
Journal: European Journal of Pharmacology - Volume 597, Issues 1–3, 12 November 2008, Pages 46–50