کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2534808 1559100 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anandamide effects on 5-HT3 receptors in vivo
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Anandamide effects on 5-HT3 receptors in vivo
چکیده انگلیسی

Studies in knockout mouse strains have shown that some cannabimimetic effects persist in animals lacking cannabinoid CB1 and CB2 receptors. These residual effects are thought to result, in part, from a cannabinoid-modulation of ion channels. This study investigates the role of 5-HT3 receptors as a potential in vivo target for cannabinoids. Mice deficient in CB1 and CB2 receptors were treated with Δ9-tetrahydrocannabinol and anandamide, in the presence of the 5-HT3 antagonist ondansetron. We show that the cannabinoid receptor-independent anandamide analgesia, but not catalepsy, is completely blocked by ondansetron. Thus, 5-HT3 receptors seem to be involved in cannabinoid analgesia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 596, Issues 1–3, 31 October 2008, Pages 98–101
نویسندگان
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