کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2534997 1559103 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
S-petasin and butterbur lactones dilate vessels through blockage of voltage gated calcium channels and block DNA synthesis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
S-petasin and butterbur lactones dilate vessels through blockage of voltage gated calcium channels and block DNA synthesis
چکیده انگلیسی

Eremophilanlactones isolated from roots of Petasites hybridus (L.) G.M. et Sch. (Asteraceae) and S-petasin have vasodilatory effects with pD2 − log (EC50) values of 6.01 ± 0.08, 5.24 ± 0.10, 4.74 ± 0.13, and 5.43 ± 0.06 for S-petasin, the (Z)-3-methylthioacrylic ester of 2β-hydroxy-8βH-7(11)-eremophilene-12,8-olide, the angelic ester of 2β-hydroxy-8αH-7(11)-eremophilene-12,8-olide, and the angelic ester of 2β-hydroxy-8βH-7(11)-eremophilene-12,8-olide, respectively, in the mesenteric arteries. The pD2 values were somewhat lower for all compounds in aortic segments. The vasodilation was caused by a blockage of the voltage gated calcium channels. S-petasin, (Z)-3-methylthioacrylic ester of 2β-hydroxy-8βH-7(11)-eremophilene-12,8-olide, and the angelic ester of 2β-hydroxy-8αH-7(11)-eremophilene-12,8-olide displayed similar potencies in inhibiting DNA synthesis in cardiomyocytes and vascular smooth muscle cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 593, Issues 1–3, 28 September 2008, Pages 79–86
نویسندگان
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