کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2535088 | 1559107 | 2008 | 4 صفحه PDF | دانلود رایگان |
C6 glioma cells were treated with clinically relevant concentrations of valproic acid (0.5 or 1.0 mM) for 1–7 days and RT-PCR used to examine expression of the melatonin MT1 receptor and selected epigenetic modulators. Valproic acid caused significant time-dependent changes in the mRNA expression of the melatonin MT1 receptor, histone deacetylase (HDAC) 1, 2 and 3, and methyl CpG binding protein 2 (MeCP2). A structurally distinct HDAC inhibitor, trichostatin A, also caused a significant concentration-dependent induction of melatonin MT1 receptor mRNA expression, suggesting involvement of an epigenetic mechanism. The ability of clinical concentrations of valproic acid to significantly alter melatonin MT1 receptor expression, suggests a role for this receptor in the diverse neuropharmacological and oncostatic effects of this agent.
Journal: European Journal of Pharmacology - Volume 589, Issues 1–3, 28 July 2008, Pages 45–48