کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2535092 | 1559107 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Blockade of sensory abnormalities and kinin B1 receptor expression by N-Acetyl-l-Cysteine and ramipril in a rat model of insulin resistance
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Male Wistar rats (50-75Â g) were given 10% d-glucose in their drinking water for 11Â weeks or tap water (controls). Glucose-fed rats were treated either with NAC (1Â g/kg/day, gavage), ramipril (1Â mg/kg/day in drinking water) or no drug during the last 5Â weeks. Glucose feeding for 6Â weeks induced a significant increase in systolic blood pressure and hyperglycaemia which was accompanied by tactile and cold allodynia. At 11Â weeks, plasma insulin, insulin resistance (HOMA index), kinin B1 receptor mRNA in spinal cord and renal cortex and B1 receptor binding sites in spinal cord were enhanced in glucose-fed rats. NAC and ramipril caused a progressive to complete inhibition of tactile and cold allodynia from 6 to 11Â weeks. High systolic blood pressure, hyperinsulinemia, insulin resistance and kinin B1 receptor expression were also normalized or attenuated in glucose-fed rats by either treatment. Results suggest that chronic treatment with an antioxidant or an ACE inhibitor provides similar beneficial effects on sensory polyneuropathy, hypertension and insulin resistance in glucose-fed rats. Both therapies were associated with a reduction of the expression of the pro-nociceptive kinin B1 receptor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 589, Issues 1â3, 28 July 2008, Pages 66-72
Journal: European Journal of Pharmacology - Volume 589, Issues 1â3, 28 July 2008, Pages 66-72
نویسندگان
Mahmoud Ali Ismael, Sébastien Talbot, Cynthia L. Carbonneau, Christian M. Beauséjour, Réjean Couture,